DunedinPACE
epigenetic method · published 2022 · measured from blood (DNA methylation, Illumina array)
epigenetic
open
Output: Pace of aging (ratio; 1.0 = one year of biological aging per calendar year)
Facts
| Method type | epigenetic |
|---|---|
| Published | 2022 |
| Sample type | blood (DNA methylation, Illumina array) |
| Output | Pace of aging (ratio; 1.0 = one year of biological aging per calendar year) |
| Validated population | Dunedin Multidisciplinary Health and Development Study (New Zealand birth cohort, born 1972-73); replicated in independent external cohorts within the same paper |
| Open or commercial | open |
| Formula publicly available | Yes — Published DunedinPACE R package (open source algorithm) |
Required inputs
- Genome-wide DNA methylation array (blood)
Original publication
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, Harrington HL, Houts R, Kothari M, Kwon D, Mill J, Schwartz J, Vokonas P, Wang C, Williams BS, Moffitt TE. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022;11:e73420.
DOI: 10.7554/eLife.73420 · PMID: 35029144
Limitations
- Trained on a single New Zealand birth cohort with repeated-measures phenotypic decline as the outcome.
- Measures rate of change, not a cumulative 'age' value — not directly comparable to PhenoAge or GrimAge output.